In its early stages, its symptoms are often silent or non-specific, making it very difficult to diagnose. Often, the only way to surely diagnose NASH is liver biopsy. For that reason, NASH patients can be unaware of their deteriorating condition until their disease reaches its late stages.
NASH may progress to more serious stages of the disease such as advanced fibrosis, liver failure, cirrhosis, liver cancer, caused by inflammation and hepatocellular ballooning. Patients with NASH-related cirrhosis are at higher risk of terminal liver diseases, such as loss of liver function, liver failure, and liver cancer.
Weight loss can reduce fat in the liver, reduce inflammation and fibrosis, even scarring. No medication is recommended for the treatment of fatty liver or NASH. The meds are recommended only to treat underlying conditions such as diabetes or heart disease. Make an appointment with your doctor if you have persistent signs and symptoms that cause you concern.
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You will also receive emails from Mayo Clinic on the latest health news, research, and care. Experts don't know exactly why some people accumulate fat in the liver while others do not.
Similarly, there is limited understanding of why some fatty livers develop inflammation that progresses to cirrhosis. These combined health problems appear to promote the deposit of fat in the liver. For some people, this excess fat acts as a toxin to liver cells, causing liver inflammation and NASH , which may lead to a buildup of scar tissue in the liver.
A normal liver left shows no signs of scarring. In cirrhosis right , scar tissue replaces normal liver tissue. Esophageal varices are enlarged veins in the esophagus. They're often due to obstructed blood flow through the portal vein, which carries blood from the intestine, pancreas and spleen to the liver.
Liver cancer begins in the cells of the liver. The most common form of liver cancer begins in cells called hepatocytes and is called hepatocellular carcinoma. Cirrhosis occurs in response to liver injury, such as the inflammation in NASH. As the liver tries to halt inflammation, it produces areas of scarring fibrosis. With continued inflammation, fibrosis spreads to take up more and more liver tissue. Nonalcoholic fatty liver disease care at Mayo Clinic.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version. NAFLD can affect people of any age, including children.
People with NASH can develop liver complications, such as cirrhosis and liver cancer. If cirrhosis leads to liver failure , you may need a liver transplant. People with NASH have an increased chance of dying from liver-related causes.
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